APCMIN/+ MOUSE MODEL OF COLON CANCER
APCMin/+ mouse model of colorectal cancer reproduces the cancer development process in vivo. APCMin/+ develop multiple adenomas in the intestine and is widely used for drug testing.
METASTATIC CANCER MODELS
Metastatic models can be induced by tail vein or intracardial injection of tumor cells. Orthotopic tumors can also develop metastases. SIA offers expertise in the establishment of metastatic models of Lung cancer, Melanoma and more.
PATIENT DERIVED XENOGRAFT PDX
Orthotopic transplantation of patient derived cells or scaffolds bearing patient derived cells can be performed. PDX implantation under the renal capsule is of interest to many of our customers owing to the high vascularization of the sub-capsular region.
FIND YOUR MODEL
At SIA, we have an expertise in oncology studies using xenograft models, transgenic mice, orthotopic tumor models, metastatic cancer and chemically-induced cancer. SIA maintains a broad panel of human and murine cancer cell-lines, which induce tumors when injected subcutaneously or orthotopically into the original organ.
Tumor, serum and organ samples can be isolated for further analyses including histology, biomarker analyses, gene expression and more. An array of ex-vivo methods to monitor cell behavior and cell death are offered by SIA.
SUBCUTANEOUS TUMOR MODELS
Subcutaneously implanted tumor cells represent a convenient means to test novel potential anticancer drugs in vivo. Caliper-based methods are used to evaluate tumor growth. SIA provides full services for efficacy studies in subcutaneous xenograft models of Lung Cancer, Colon Cancer, Breast Cancer, Prostate Cancer, Pancreatic Cancer and more.
ORTHOTOPIC TUMOR MODELS
SIA has experience and skill in orthotopic tumor implantation experiments and study design. We offer orthotopic cancer models of breast, colon, ovarian, lung, pancreas, kidney, prostate, brain, gastric and more. We frequently establish and validate custom models tailored to our clients specific research needs. Several immunocompetent or immunodeficient mouse models can be used. Please contact us for consultation on model selection.
The combination of azoxymethane (AOM) with an inflammatory agent Dextran Sodium Sulfate (DSS) recapitulates in rodents the aberrant crypt foci-adenoma-carcinoma sequence that occurs in human colorectal cancer.