FIND YOUR MODEL
Genetic mouse models of muscular dystropy are available and SIA is highly experienced with muscle dystrophy research. Evaluation of muscle function is performed through rotarod and grip-strength automated tests.
At study completion, samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA.
DUCHENNE MUSCULAR DYSTROPHY DMD
DMD is the most common fatal genetic disorder diagnosed in childhood, affecting approximately 1 in every 3,500 infants born. In this disease, a point mutation in the dystrophin gene leads to it’s aberrant form or complete absence. This results in progressive muscle weakness and severe medical problems, particularly conditions relating to the heart and lungs. Young men with Duchenne typically live into their late twenties.
Serum Creatinine Phosphokinase (CPK) and motor function tests are used to monitor disease progression.
For detailed information on DMD animal models, please contact us.