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SIA has vast experience and expertise in animal models of human dermal pathologies. Here are examples of dermatological animal models. For more information, please contact us.
At study completion, samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA.
Psoriasis-like skin inflammation with activation of cellular immune compartment and cytokines characteristic of human psoriatic lesions can be induced in mice by topical application of imiquimod (IMQ) cream. IMQ cream is used in clinic to treat warts caused by human papilloma virus. IMQ applied to mouse skin, activates inflammatory reaction and induces skin inflammation closely resembling human psoriatic lesions.