FIND YOUR MODEL
Kidney diseases result from recurrent or progressive kidney injuries. 5/6 nephrectomy and Acute Kidney Injury (AKI) models in mice and rats recreate pathophysiological features of human kidney disease.
Upon model establishment, animals are housed in metabolic cages. Readouts include urine and serum analysis. Additionally, samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA.
5/6 NEPHRECTOMY IN RATS AND MICE
Experimental model of 5/6 nephrectomy or the remnant kidney model represents one of the most used animal models of progressive renal failure by reduced nephron number. It enables to investigate the influence of pharmacological, nutritive and other factors on functional and morphological renal parameters. We have extensive experience in the 5/6 nephrectomy model in both rats and mice.
ACUTE KIDNEY INJURY AKI
The Acute Kidney Injury (AKI) or Kidney Ischemia Reperfusion model (also called renal ischemia and nephric ischemia) is used to assess deficiency of blood flow in the kidney. The renal artery is transiently occluded using a nontraumatic micro aneurysm clamp. Following occlusion period, the clamp is removed to allow reperfusion.