CONTACT FORM

SCIENCE IN ACTION | Raanan Margalit, CEO | +972-52-3400426 | raanan.margalit@gmail.com

3 Pinchas Sapir St., Weizmann Science Park Ness Ziona, ISRAEL

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FIND YOUR MODEL

SYSTEMIC LUPUS ERYTHEMATOSUS

 

Systemic lupus erythematosus (SLE) is a severe systemic chronic autoimmune disease.

 

SIA provides full services for the evaluation of test article efficacy in a mouse model of SLE. SLE development is monitored by periodic analysis of blood and urine samples. 

 

Additionally, samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo studies offered by SIA.

NZB/W F1 mouse model of SLE

NZB/W F1 MOUSE MODEL OF SLE

New Zealand Black X New Zealand White (NZB/W) F1 mice are commonly used to study SLE.  NZB/W F1 mice spontaneously develop severe SLE-like phenotypes comparable to those of SLE patients. These SLE-like phenotypes include lymphadenopathy, splenomegaly, elevated serum antinuclear autoantibodies (ANA) and immune complex-mediated glomerulonephritis (GN) that becomes apparent at 5-6 months of age, leading to kidney failure and death at 10–12 months of age.