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CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Chronic obstructive pulmonary disease (COPD), characterized by emphysema and chronic bronchitis, is one of the leading causes of death worldwide, and therefore is a major public health concern. Emphysema is a progressive condition of airspace enlargement leading to a decline in lung function. A mouse model of emphysema induced by elastase recapitulates the features of human COPD.

ALLERGEN-INDUCED ASTHMA MODEL

In addition to OVA, other allergens of choice may be used for sensitization and subsequent challenge to induce a specific allergen-challenged rodent asthma model.

OVALBUMIN-INDUCED ASTHMA MODEL IN MICE AND RATS

Ovalbumin-induced allergic asthma reproduces in rodents the airway eosinophilia, pulmonary inflammation and elevated IgE levels characteristic to human asthma.

FIND YOUR MODEL

LUNG DISORDERS

SIA provides a range of in vivo models for the research of respiratory diseases with a focus on Asthma and Chronic Obstructive Pulmonary Disease (COPD). 

According to the specific needs of the test article, Intranasal or Intra-tracheal drug administration is applied.

 

Endpoint analysis may include airway hyper-responsiveness measurements, histological analysis, bronchoalveolar lavage fluid and serum analysis. 

Additionally, samples can be isolated for further analyses including serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo studies offered by SIA (link).

Ovalbumin-Induced Asthma Model in Mice and Rats

Allergen-Induced asthma model

Chronic Obstructive Pulmonary Disease