In diet-induced obesity models, rats or mice, are fed a high fat diet to induce weight gain, diabetes, high blood pressure and other obesity associated phenotypes. Typically, animals become obese, mildly to moderately hyperglycemic, develop impaired glucose tolerance and fatty liver.
Feeding mice or rats high fat diet results in hepatocellular changes consistent with fatty liver disease and oxidative stress in the liver. Increased serum levels of fatty liver disease bio-markers are characteristic features of diet-induced obesity animal model.
OB/OB MOUSE MODEL
This strain is used to model diabetes type II and obesity. Obesity is characterized by an increase in the number and size of adipocytes. In ob/ob mice, hyperphagia contributes to the obesity, and these mice gain excess weight even when restricted to a diet sufficient for normal weight maintenance.
Ob/ob mice are hyperinsulinaemic, hyperglycaemic, resistant to insulin and develop spontaneous liver steatosis. Large vacuoles of triglyceride fat are evident in liver histology of ob/ob mice.
FIND YOUR MODEL
OBESITY/FATTY LIVER DISEASE
Obesity is highly associated with nonalcoholic fatty liver disease with about 90 percent of morbidly obese patients showing histological abnormalities of the liver. Animal models of obesity show a distinct phenotype of obesity, hyperphagia, change in energy metabolism and hepatic abnormalities.
Samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA.