STREPTOZOTOCIN STZ INDUCED DIABETES MODELS
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction and thus inhibition of the insulin secretary mechanism. It is widely used chemical agent producing Type-I Diabetes in experimental animals. Administration of different doses can produce mild, moderate and severe diabetic condition. Diabetes can be induced by STZ in mice or in rats. Animal strain and STZ dose is customized to correspond with your needs.
FIND YOUR MODEL
DIABETES TYPE I
Animal models of diabetes mellitus type 1 are used to study potential new therapeutic agents since they reproduce the pathophysiology of the human disease. SIA has the expertise in diabetes type I animal models in mice and rats and offers free consultation on model selection and study design (contact).
Treatment can be delivered by a variety of methods including regular delivery routes or implantation of specialized devices, therapeutic cells or scaffolds. Cell therapy and scaffolds can be implanted orthotopically into intramesenteric site.
Samples can be isolated for further analyses including histology serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA (link).
NON-OBESE DIABETIC (NOD) MICE
NOD mice develop spontaneous autoimmune type I diabetes, mimicking many features of the human disease. Diabetes in NOD mice is characterized by insulitis, a mononuclear infiltrate of the pancreatic islets. Marked decreases in pancreatic insulin content occur in females at about 12 weeks of age and several weeks later in males. Diabetic mice are hypoinsulinemic and hyperglucagonemic.